After conquering central Mexico, the Aztecs divided the region that constitutes modern-day Guerrero into seven entities.
The natural harbor at Acapulco enabled trade with Asia, and while the rough and dangerous road between Acapulco and Mexico City took 12 days to travel, the prospect of lucrative overseas trade made it one of the busiest colonial routes in Mexico.
Trade become common during this period between Acapulco and destinations such as Peru and Asia.
Many constitutionalist and liberal leaders sought refuge in Guerrero, where they attempted to reorganize their opposition to French Emperor Maximilian II.
Benito Juárez, Mexico’s ex-president (1861-1872), led the opposition to the French empire and was supported by Ignacio Manuel Altamirano, a Guerrero writer and journalist of Nahua descent.
One part of Guerrero, Acapulco, never came under the direct control of the Aztecs but instead remained subject to local caciques (chiefs).